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Article

Mortality is associated with apolipoprotein E epsilon4 in nondemented adults with Down syndrome.

Neuroscience letters - 23 Dec 2005

Zigman Warren B, Jenkins Edmund C, Tycko Benjamin, Schupf Nicole, Silverman Wayne

Abstract excerpt

Apolipoprotein E genotype has been related to survival in the general population, but its strong association with Alzheimer's disease (AD) makes interpretation of findings difficult. Previous studies of adults with Down syndrome (DS) have consistently found that the presence of the apolipoprotein E epsilon2 allele increases longevity and reduces the risk of dementia, while the apolipoprotein E epsilon4 allele...

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Identifiers

PMID: 16122874
DOI: 10.1016/j.neulet.2005.08.002

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Mortality is associated with apolipoprotein E epsilon4 in nondemented adults with Down syndrome.PMID 16122874Read ↗

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Onset of dementia is associated with apolipoprotein E epsilon4 in Down's syndrome.Semantic proximity Read ↗

Is Apolipoprotein E4 an Important Risk Factor for Dementia in Persons with Down Syndrome?Semantic proximity Read ↗

The impact of apolipoprotein E on dementia in persons with Down's syndrome.Semantic proximity Read ↗

Apo E genotypes and risk of dementia in Down syndrome.Semantic proximity Read ↗

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A protective effect of apolipoprotein E e2 allele on dementia in Down's syndrome.Semantic proximity Read ↗

Little evidence of reduced survival to adulthood of apoE epsilon4 homozygotes in Down's syndrome.Semantic proximity Read ↗

APOE epsilon 4 influences the manifestation of Alzheimer's disease in adults with Down's syndrome.Semantic proximity Read ↗

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