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Article

Apo E genotypes and risk of dementia in Down syndrome.

American journal of medical genetics - 20 Aug 1999

Rubinsztein D C, Hon J, Stevens F, Pyrah I, Tysoe C, Huppert F A, Easton D F, Holland A J

Abstract excerpt

The relationship between apo E genotypes and risk of dementia in Down syndrome is not clear. Accordingly, we have analysed this locus in 20 demented and 25 nondemented individuals with Down syndrome and combined these data with other studies in a meta-analysis. The meta-analysis revealed an estimated odds ratio for dementia of 2.74 (95% CI 1.34-5.58) (P =.0004) for apo epsilon4 carriers compared with apo...

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Source

Identifiers

PMID: 10402500
DOI: 10.1002/(sici)1096-8628(19990820)88:4<344::aid-ajmg10>3.0.co;2-1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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