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Is Apolipoprotein E4 an Important Risk Factor for Dementia in Persons with Down Syndrome?

1 Jan 2014

Abstract excerpt

Down syndrome is one of the most common genetic causes of intellectual disability and is characterized by a number of behavioral as well as cognitive symptoms. Triplication of all or part of human chromosome 21 has been considered as the main cause of Down syndrome. Due to the location of the amyloid precursor protein on chromosome 21, many of the neuropathological features of early-onset Alzheimer's disease...

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PMID: 25594074
DOI: 10.13188/2376-922x.1000004

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