Onset of dementia is associated with apolipoprotein E epsilon4 in Down's syndrome.

doi:10.1002/ana.410400518

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Article

Onset of dementia is associated with apolipoprotein E epsilon4 in Down's syndrome.

Annals of neurology - 1 Nov 1996

Schupf N, Kapell D, Lee J H, Zigman W, Canto B, Tycko B, Mayeux R

Abstract excerpt

We examined the influence of apolipoprotein E (apoE) genotype on risk of dementia in 82 adults with Down's syndrome (DS). Compared with those with an apoE 3/3 genotype, the group of adults with DS with apoE 2/4, 3/4, and 4/4 genotypes were 5 times more likely to become demented (RR = 4.7; 95% CI...

Topics

Adult
Aged
Apolipoprotein E4
Apolipoproteins E
Dementia
Down Syndrome
Female
Genotype
Humans
Incidence
Male
Middle Aged
Risk Assessment
Risk Factors

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