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Article

APOE epsilon 4 influences the manifestation of Alzheimer's disease in adults with Down's syndrome.

The British journal of psychiatry : the journal of mental science - 1 May 2000

Deb S, Braganza J, Norton N, Williams H, Kehoe P G, Williams J, Owen M J

Abstract excerpt

BACKGROUND: Recent studies of the relationship between the apolipoprotein E (APOE) gene and Alzheimer's disease in adults with Down's syndrome have revealed inconsistent results. AIMS: To assess the role of the APOE gene in the manifestation of Alzheimer's disease in adults with Down's syndrome. METHOD: We studied the APOE genotypes of 24 adults with dementia and 33 non-demented adults with Down's syndrome over...

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Source

Identifiers

PMID: 10912224
DOI: 10.1192/bjp.176.5.468

Genes

APOE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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