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Article

Decreased catalytic activity of the insulin-degrading enzyme in chromosome 10-linked Alzheimer disease families.

The Journal of biological chemistry - 16 Mar 2007

Kim Minji, Hersh Louis B, Leissring Malcolm A, Ingelsson Martin, Matsui Toshifumi, Farris Wesley, Lu Alice, Hyman Bradley T, Selkoe Dennis J, Bertram Lars, Tanzi Rudolph E

Abstract excerpt

Insulin-degrading enzyme (IDE) is a zinc metalloprotease that degrades the amyloid beta-peptide, the key component of Alzheimer disease (AD)-associated senile plaques. We have previously reported evidence for genetic linkage and association of AD on chromosome 10q23-24 in the region harboring the IDE gene. Here we have presented the first functional assessment of IDE in AD families showing the strongest evidence...

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Identifiers

PMID: 17244626
DOI: 10.1074/jbc.M609168200

Genes

IDE

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Decreased catalytic activity of the insulin-degrading enzyme in chromosome 10-linked Alzheimer disease families.PMID 17244626Read ↗

Genetic variation in a haplotype block spanning IDE influences Alzheimer disease.Semantic proximity Read ↗

Reduced hippocampal insulin-degrading enzyme in late-onset Alzheimer's disease is associated with the apolipoprotein E-epsilon4 allele.Semantic proximity Read ↗

Substantial linkage disequilibrium across the insulin-degrading enzyme locus but no association with late-onset Alzheimer's disease.Semantic proximity Read ↗

Evidence for genetic linkage of Alzheimer's disease to chromosome 10q.Semantic proximity Read ↗

Polymorphisms of insulin degrading enzyme gene are not associated with Alzheimer's disease.Semantic proximity Read ↗

Concordant Association of Insulin Degrading Enzyme Gene (IDE) Variants with IDE mRNA, Aß, and Alzheimer's DiseaseSemantic proximity Read ↗

Insulin-degrading enzyme, apolipoprotein E, and Alzheimer's disease.Semantic proximity Read ↗

No association between the insulin degrading enzyme gene and Alzheimer's disease in a Japanese population.Semantic proximity Read ↗

Insulin-degrading enzyme and Alzheimer disease: a genetic association study in the Han Chinese.Semantic proximity Read ↗

Positive association between risk for late-onset Alzheimer disease and genetic variation in IDE.Semantic proximity Read ↗

Association studies between risk for late-onset Alzheimer's disease and variants in insulin degrading enzyme.Semantic proximity Read ↗

Lack of association of 5 SNPs in the vicinity of the insulin-degrading enzyme (IDE) gene with late-onset Alzheimer's disease.Semantic proximity Read ↗

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