Article
Reduced hippocampal insulin-degrading enzyme in late-onset Alzheimer's disease is associated with the apolipoprotein E-epsilon4 allele.
The American journal of pathology - 1 Jan 2003
Cook David G, Leverenz James B, McMillan Pamela J, Kulstad J Jacob, Ericksen Sasha, Roth Richard A, Schellenberg Gerard D, Jin Lee-Way, Kovacina Kristina S, Craft Suzanne
Abstract excerpt
Abeta is the major component of amyloid plaques characterizing Alzheimer's disease (AD). Abeta accumulation can be affected by numerous factors including increased rates of production and/or impaired clearance. Insulin-degrading enzyme (IDE) has been implicated as a candidate enzyme responsible for the degradation and clearance of Abeta in the brain. We have previously shown that AD patients exhibit abnormalities...
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