Article
Association studies between risk for late-onset Alzheimer's disease and variants in insulin degrading enzyme.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics - 5 Jul 2005
Nowotny Petra, Hinrichs Anthony L, Smemo Scott, Kauwe John S K, Maxwell Taylor, Holmans Peter, Hamshere Marian, Turic Dragana, Jehu Luke, Hollingworth Paul, Moore Pamela, Bryden Leslie, Myers Amanda, Doil Lisa M, Tacey Kristina M, Gibson Alison M, McKeith Ian G, Perry Robert H, Morris Chris M, Thal Leon, Morris John C, O'Donovan Michael C, Lovestone Simon, Grupe Andrew, Hardy John, Owen Michael J, Williams Julie, Goate Alison
Abstract excerpt
Linkage studies have suggested there is a susceptibility gene for late onset Alzheimer's disease (LOAD) in a broad region of chromosome 10. A strong positional and biological candidate is the gene encoding the insulin-degrading enzyme (IDE), a protease involved in the catabolism of Abeta. However, previous association studies have produced inconsistent results. To systematically evaluate the role of variation in...
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