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Article

Evidence for genetic linkage of Alzheimer's disease to chromosome 10q.

Science (New York, N.Y.) - 22 Dec 2000

Bertram L, Blacker D, Mullin K, Keeney D, Jones J, Basu S, Yhu S, McInnis M G, Go R C, Vekrellis K, Selkoe D J, Saunders A J, Tanzi R E

Abstract excerpt

Recent studies suggest that insulin-degrading enzyme (IDE) in neurons and microglia degrades Abeta, the principal component of beta-amyloid and one of the neuropathological hallmarks of Alzheimer's disease (AD). We performed parametric and nonparametric linkage analyses of seven genetic markers on chromosome 10q, six of which map near the IDE gene, in 435 multiplex AD families. These analyses revealed significant...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 11125142
DOI: 10.1126/science.290.5500.2302

Genes

IDE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Evidence for genetic linkage of Alzheimer's disease to chromosome 10q.PMID 11125142Read ↗

Genetic variation in a haplotype block spanning IDE influences Alzheimer disease.Semantic proximity Read ↗

Effect of heterogeneity on the chromosome 10 risk in late-onset Alzheimer disease.Semantic proximity Read ↗

Insulin-degrading enzyme is genetically associated with Alzheimer’s disease in the Finnish populationSemantic proximity Read ↗

No association between the insulin degrading enzyme gene and Alzheimer's disease in a Japanese population.Semantic proximity Read ↗

Decreased catalytic activity of the insulin-degrading enzyme in chromosome 10-linked Alzheimer disease families.Semantic proximity Read ↗

Association analysis of 528 intra-genic SNPs in a region of chromosome 10 linked to late onset Alzheimer's disease.Semantic proximity Read ↗

Positive association between risk for late-onset Alzheimer disease and genetic variation in IDE.Semantic proximity Read ↗

Susceptibility gene(s) for Alzheimer's disease on chromosome 10.Semantic proximity Read ↗

Substantial linkage disequilibrium across the insulin-degrading enzyme locus but no association with late-onset Alzheimer's disease.Semantic proximity Read ↗

A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease.Semantic proximity Read ↗

Association studies between risk for late-onset Alzheimer's disease and variants in insulin degrading enzyme.Semantic proximity Read ↗

Susceptibility locus for Alzheimer's disease on chromosome 10.Semantic proximity Read ↗

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