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Article

Positive association between risk for late-onset Alzheimer disease and genetic variation in IDE.

Neurobiology of aging - 1 Sept 2007

Björk Behnosh F, Katzov Hagit, Kehoe Patrick, Fratiglioni Laura, Winblad Bengt, Prince Jonathan A, Graff Caroline

Abstract excerpt

Insulin degrading enzyme (IDE) is one of the principal proteases involved in the degradation of the beta-amyloid peptide, which is the major constituent of senile plaques in Alzheimer's disease (AD) brains. Previous association studies between AD and IDE have produced inconsistent results which may be indicative of a need for larger case-control series to identify what may be a relatively small effect size. Thus,...

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Source

Identifiers

PMID: 16876916
DOI: 10.1016/j.neurobiolaging.2006.06.017

Genes

IDE

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Positive association between risk for late-onset Alzheimer disease and genetic variation in IDE.PMID 16876916Read ↗

Association studies between risk for late-onset Alzheimer's disease and variants in insulin degrading enzyme.Semantic proximity Read ↗

Genetic variation in a haplotype block spanning IDE influences Alzheimer disease.Semantic proximity Read ↗

Lack of association of 5 SNPs in the vicinity of the insulin-degrading enzyme (IDE) gene with late-onset Alzheimer's disease.Semantic proximity Read ↗

Concordant Association of Insulin Degrading Enzyme Gene (IDE) Variants with IDE mRNA, Aß, and Alzheimer's DiseaseSemantic proximity Read ↗

Disorder-specific effects of polymorphisms at opposing ends of the Insulin Degrading Enzyme gene.Semantic proximity Read ↗

Weak independent association signals between IDE polymorphisms, Alzheimer's disease and cognitive measures.Semantic proximity Read ↗

Insulin-degrading enzyme is genetically associated with Alzheimer’s disease in the Finnish populationSemantic proximity Read ↗

Sequence variants of IDE are associated with the extent of beta-amyloid deposition in the Alzheimer's disease brain.Semantic proximity Read ↗

Insulin degrading enzyme (IDE) genetic variants and risk of Alzheimer's disease: evidence of effect modification by apolipoprotein E (APOE).Semantic proximity Read ↗

Insulin-degrading enzyme and Alzheimer disease: a genetic association study in the Han Chinese.Semantic proximity Read ↗

No association between the insulin degrading enzyme gene and Alzheimer's disease in a Japanese population.Semantic proximity Read ↗

Exploration of 16 candidate genes identifies the association of IDE with Alzheimer's disease in Han Chinese.Semantic proximity Read ↗

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