Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Insulin-degrading enzyme and Alzheimer disease: a genetic association study in the Han Chinese.

Neurology - 27 Jul 2004

Bian L, Yang J D, Guo T W, Sun Y, Duan S W, Chen W Y, Pan Y X, Feng G Y, He L

Abstract excerpt

BACKGROUND: The gene for insulin-degrading enzyme (IDE) represents a strong positional and biologic candidate for late-onset Alzheimer disease (LOAD) susceptibility. IDE is located on chromosome 10q23.3 close to a region of linkage for LOAD. In addition, many studies have identified a possible role of IDE in the degradation of amyloid beta-protein and the intracellular amyloid precursor protein (APP) domain...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Age of Onset
Share to Alzheimer Disease
Share to Apolipoprotein E4

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Apolipoproteins E

Share to Chromosomes, Human, Pair 10

Share to Ethnicity

Share to Insulysin

Source

Identifiers

PMID: 15277615
DOI: 10.1212/01.wnl.0000129987.70037.db

Genes

IDE
APOE
APP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Insulin-degrading enzyme and Alzheimer disease: a genetic association study in the Han Chinese.PMID 15277615Read ↗

Association between polymorphisms of the insulin-degrading enzyme gene and late-onset Alzheimer disease.Semantic proximity Read ↗

Concordant Association of Insulin Degrading Enzyme Gene (IDE) Variants with IDE mRNA, Aß, and Alzheimer's DiseaseSemantic proximity Read ↗

Insulin-degrading enzyme, apolipoprotein E, and Alzheimer's disease.Semantic proximity Read ↗

The association between two single nucleotide polymorphisms within the insulin-degrading enzyme gene and Alzheimer's disease in a Chinese Han population.Semantic proximity Read ↗

Exploration of 16 candidate genes identifies the association of IDE with Alzheimer's disease in Han Chinese.Semantic proximity Read ↗

Insulin-degrading enzyme is genetically associated with Alzheimer’s disease in the Finnish populationSemantic proximity Read ↗

Association studies between risk for late-onset Alzheimer's disease and variants in insulin degrading enzyme.Semantic proximity Read ↗

Polymorphism Rs2421943 of the Insulin-Degrading Enzyme Gene and the Risk of Late-Onset Alzheimer's Disease.Semantic proximity Read ↗

Positive association between risk for late-onset Alzheimer disease and genetic variation in IDE.Semantic proximity Read ↗

Association of insulin degrading enzyme gene polymorphisms with Alzheimer's disease: a meta-analysis.Semantic proximity Read ↗

Insulin degrading enzyme (IDE) genetic variants and risk of Alzheimer's disease: evidence of effect modification by apolipoprotein E (APOE).Semantic proximity Read ↗

Meta-analysis of the insulin degrading enzyme polymorphisms and susceptibility to Alzheimer's disease.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.