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Article

Genetic variation in a haplotype block spanning IDE influences Alzheimer disease.

Human mutation - 1 Nov 2003

Prince Jonathan A, Feuk Lars, Gu Harvest F, Johansson Boo, Gatz Margaret, Blennow Kaj, Brookes Anthony J

Abstract excerpt

Linkage studies have identified a large (>60-Mb) region on chromosome 10q that segregates with Alzheimer Disease (AD). Within the region, the gene for insulin degrading enzyme (IDE) represents a notable biological candidate given that it degrades amyloid beta-protein (one of the major constituents of senile plaques) and the intracellular amyloid precursor protein (APP) domain released by gamma-secretase...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 14517947
DOI: 10.1002/humu.10282

Genes

IDE
APOE
APP
HHEX
MAPT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genetic variation in a haplotype block spanning IDE influences Alzheimer disease.PMID 14517947Read ↗

Sequence variants of IDE are associated with the extent of beta-amyloid deposition in the Alzheimer's disease brain.Semantic proximity Read ↗

Mutation screening of a haplotype block around the insulin degrading enzyme gene and association with Alzheimer's disease.Semantic proximity Read ↗

Genetic variants in a haplotype block spanning IDE are significantly associated with plasma Abeta42 levels and risk for Alzheimer disease.Semantic proximity Read ↗

Positive association between risk for late-onset Alzheimer disease and genetic variation in IDE.Semantic proximity Read ↗

Lack of association of 5 SNPs in the vicinity of the insulin-degrading enzyme (IDE) gene with late-onset Alzheimer's disease.Semantic proximity Read ↗

Concordant Association of Insulin Degrading Enzyme Gene (IDE) Variants with IDE mRNA, Aß, and Alzheimer's DiseaseSemantic proximity Read ↗

Sequence variation in the proximity of IDE may impact age at onset of both Parkinson disease and Alzheimer disease.Semantic proximity Read ↗

Association between variants in IDE-KIF11-HHEX and plasma amyloid β levels.Semantic proximity Read ↗

Association studies between risk for late-onset Alzheimer's disease and variants in insulin degrading enzyme.Semantic proximity Read ↗

Insulin-degrading enzyme and Alzheimer disease: a genetic association study in the Han Chinese.Semantic proximity Read ↗

Insulin degrading enzyme (IDE) genetic variants and risk of Alzheimer's disease: evidence of effect modification by apolipoprotein E (APOE).Semantic proximity Read ↗

Weak independent association signals between IDE polymorphisms, Alzheimer's disease and cognitive measures.Semantic proximity Read ↗

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