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Article

Lack of association of 5 SNPs in the vicinity of the insulin-degrading enzyme (IDE) gene with late-onset Alzheimer's disease.

Neuroscience letters - 9 Oct 2006

Ozturk Ayla, DeKosky Steven T, Kamboh M Ilyas

Abstract excerpt

Insulin-degrading enzyme (IDE) is a strong biological and positional candidate gene for Alzheimer's disease (AD). Previously some studies have examined the role of common variation in the IDE gene with AD risk but the results have been inconsistent. In this study we examined the role of 5 SNPs that define a linkage disequilibrium (LD) block spanning 276kb around IDE. Our sample comprised up to 1012 late-onset AD...

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Source

Identifiers

PMID: 16914266
DOI: 10.1016/j.neulet.2006.07.054

Genes

IDE

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Click a neighbor to travelStep 1 · 12 closest

Lack of association of 5 SNPs in the vicinity of the insulin-degrading enzyme (IDE) gene with late-onset Alzheimer's disease.PMID 16914266Read ↗

Association studies between risk for late-onset Alzheimer's disease and variants in insulin degrading enzyme.Semantic proximity Read ↗

Substantial linkage disequilibrium across the insulin-degrading enzyme locus but no association with late-onset Alzheimer's disease.Semantic proximity Read ↗

Weak independent association signals between IDE polymorphisms, Alzheimer's disease and cognitive measures.Semantic proximity Read ↗

Positive association between risk for late-onset Alzheimer disease and genetic variation in IDE.Semantic proximity Read ↗

Genetic variation in a haplotype block spanning IDE influences Alzheimer disease.Semantic proximity Read ↗

Concordant Association of Insulin Degrading Enzyme Gene (IDE) Variants with IDE mRNA, Aß, and Alzheimer's DiseaseSemantic proximity Read ↗

No association between the insulin degrading enzyme gene and Alzheimer's disease in a Japanese population.Semantic proximity Read ↗

Sequence variation in the proximity of IDE may impact age at onset of both Parkinson disease and Alzheimer disease.Semantic proximity Read ↗

Sequence variants of IDE are associated with the extent of beta-amyloid deposition in the Alzheimer's disease brain.Semantic proximity Read ↗

Polymorphisms of insulin degrading enzyme gene are not associated with Alzheimer's disease.Semantic proximity Read ↗

Association between polymorphisms of the insulin-degrading enzyme gene and late-onset Alzheimer disease.Semantic proximity Read ↗

Association studies of 22 candidate SNPs with late-onset Alzheimer's disease.Semantic proximity Read ↗

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