Article
Substantial linkage disequilibrium across the insulin-degrading enzyme locus but no association with late-onset Alzheimer's disease.
Human genetics - 1 Dec 2001
Abraham R, Myers A, Wavrant-DeVrieze F, Hamshere M L, Thomas H V, Marshall H, Compton D, Spurlock G, Turic D, Hoogendoorn B, Kwon J M, Petersen R C, Tangalos E, Norton J, Morris J C, Bullock R, Liolitsa D, Lovestone S, Hardy J, Goate A, O'Donovan M, Williams J, Owen M J, Jones L
Abstract excerpt
Insulin-degrading enzyme (IDE; insulysin; EC 3.4.24.56) is a 110-kDa neutral metallopeptidase that can degrade a number of peptides including beta-amyloid. The gene encoding IDE is located on chromosome 10 close to a region of linkage for late-onset Alzheimer's disease (LOAD) and thus is a functional and positional candidate for this disorder. We analysed all of the coding exons, untranslated regions and 1000 bp...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.