Article
Improved glucose tolerance in acyl CoA:diacylglycerol acyltransferase 1-null mice is dependent on diet.
Lipids in health and disease - 19 Jan 2007
Wang Steven J Y, Cornick Claire, O'Dowd Jacqueline, Cawthorne Michael A, Arch Jonathan R S
Abstract excerpt
BACKGROUND: Mice that lack acyl CoA:diacylglycerol acyltransferase (Dgat1-/- mice) are reported to have a reduced body fat content and improved glucose tolerance and insulin sensitivity. Studies so far have focussed on male null mice fed a high fat diet and there are few data on heterozygotes. We compared male and female Dgat1-/-, Dgat1+/- and Dgat1+/+ C57Bl/6 mice fed on either standard chow or a high fat diet....
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