Article
AKR1D1 knockout mice develop a sex-dependent metabolic phenotype.
The Journal of endocrinology - 13 Apr 2022
Gathercole Laura L, Nikolaou Nikolaos, Harris Shelley E, Arvaniti Anastasia, Poolman Toryn M, Hazlehurst Jonathan M, Kratschmar Denise V, Todorčević Marijana, Moolla Ahmad, Dempster Niall, Pink Ryan C, Saikali Michael F, Bentley Liz, Penning Trevor M, Ohlsson Claes, Cummins Carolyn L, Poutanen Matti, Odermatt Alex, Cox Roger D, Tomlinson Jeremy W
Abstract excerpt
Steroid 5β-reductase (AKR1D1) plays important role in hepatic bile acid synthesis and glucocorticoid clearance. Bile acids and glucocorticoids are potent metabolic regulators, but whether AKR1D1 controls metabolic phenotype in vivo is unknown. Akr1d1-/- mice were generated on a C57BL/6 background. Liquid chromatography/mass spectrometry, metabolomic and transcriptomic approaches were used to determine effects on...
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