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Article

CREG1 heterozygous mice are susceptible to high fat diet-induced obesity and insulin resistance.

PloS one - 1 Jan 2017

Tian Xiaoxiang, Yan Chenghui, Liu Meili, Zhang Quanyu, Liu Dan, Liu Yanxia, Li Shaohua, Han Yaling

Abstract excerpt

Cellular repressor of E1A-stimulated genes 1 (CREG1) is a small glycoprotein whose physiological function is unknown. In cell culture studies, CREG1 promotes cellular differentiation and maturation. To elucidate its physiological functions, we deleted the Creg1 gene in mice and found that loss of CREG1 leads to early embryonic death, suggesting that it is essential for early development. In the analysis of Creg1...

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Share to 3T3-L1 Cells
Share to Adipocytes
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Diet, High-Fat

Share to Haploinsufficiency

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Source

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Identifiers

PMID: 28459882
DOI: 10.1371/journal.pone.0176873
PMCID: PMC5411056

Genes

CREG1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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