Article
Caveolin-1-deficient mice are lean, resistant to diet-induced obesity, and show hypertriglyceridemia with adipocyte abnormalities.
The Journal of biological chemistry - 8 Mar 2002
Razani Babak, Combs Terry P, Wang Xiao Bo, Frank Philippe G, Park David S, Russell Robert G, Li Maomi, Tang Baiyu, Jelicks Linda A, Scherer Philipp E, Lisanti Michael P
Abstract excerpt
Caveolae organelles and caveolin-1 protein expression are most abundant in adipocytes and endothelial cells. Our initial report on mice lacking caveolin-1 (Cav-1) demonstrated a loss of caveolae and perturbations in endothelial cell function. More recently, however, observation of the Cav-1-deficient cohorts into old age revealed significantly lower body weights, as compared with wild-type controls. These results...
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