Article
Deletion of CDKAL1 affects high-fat diet-induced fat accumulation and glucose-stimulated insulin secretion in mice, indicating relevance to diabetes.
PloS one - 1 Jan 2012
Okamura Tadashi, Yanobu-Takanashi Rieko, Takeuchi Fumihiko, Isono Masato, Akiyama Koichi, Shimizu Yukiko, Goto Motohito, Liang Yi-Qiang, Yamamoto Ken, Katsuya Tomohiro, Fujioka Akihiro, Ohnaka Keizo, Takayanagi Ryoichi, Ogihara Toshio, Yamori Yukio, Kato Norihiro
Abstract excerpt
BACKGROUND/OBJECTIVE: The CDKAL1 gene is among the best-replicated susceptibility loci for type 2 diabetes, originally identified by genome-wide association studies in humans. To clarify a physiological importance of CDKAL1, we examined effects of a global Cdkal1-null mutation in mice and also evaluated the influence of a CDKAL1 risk allele on body mass index (BMI) in Japanese subjects. METHODS: In...
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