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Prevention of hepatic steatosis and hepatic insulin resistance in mitochondrial acyl-CoA:glycerol-sn-3-phosphate acyltransferase 1 knockout mice.

Cell metabolism - 1 Jul 2005

Neschen Susanne, Morino Katsutaro, Hammond Linda E, Zhang Dongyan, Liu Zhen-Xiang, Romanelli Anthony J, Cline Gary W, Pongratz Rebecca L, Zhang Xian-Man, Choi Cheol S, Coleman Rosalind A, Shulman Gerald I

Abstract excerpt

In order to investigate the role of mitochondrial acyl-CoA:glycerol-sn-3-phosphate acyltransferase 1 (mtGPAT1) in the pathogenesis of hepatic steatosis and hepatic insulin resistance, we examined whole-body insulin action in awake mtGPAT1 knockout (mtGPAT1(-/-)) and wild-type (wt) mice after regular control diet or three weeks of high-fat feeding. In contrast to high-fat-fed wt mice, mtGPAT1(-/-) mice displayed...

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PMID: 16054099
DOI: 10.1016/j.cmet.2005.06.006

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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