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Article

Deficiency of the lipid synthesis enzyme, DGAT1, extends longevity in mice.

Aging - 1 Jan 2012

Streeper Ryan S, Grueter Carrie A, Salomonis Nathan, Cases Sylvaine, Levin Malin C, Koliwad Suneil K, Zhou Ping, Hirschey Mattew D, Verdin Eric, Farese Robert V

Abstract excerpt

Calorie restriction results in leanness, which is linked to metabolic conditions that favor longevity. We show here that deficiency of the triglyceride synthesis enzyme acyl CoA:diacylglycerol acyltransferase 1 (DGAT1), which promotes leanness, also extends longevity without limiting food intake. Female DGAT1-deficient mice were protected from age-related increases in body fat, tissue triglycerides, and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 22291164
DOI: 10.18632/aging.100424
PMCID: PMC3292902

Genes

DGAT1
IGF1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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