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Article

Dissociation of the glucose and lipid regulatory functions of FoxO1 by targeted knockin of acetylation-defective alleles in mice.

Cell metabolism - 2 Nov 2011

Banks Alexander S, Kim-Muller Ja Young, Mastracci Teresa L, Kofler Natalie M, Qiang Li, Haeusler Rebecca A, Jurczak Michael J, Laznik Dina, Heinrich Garrett, Samuel Varman T, Shulman Gerald I, Papaioannou Virginia E, Accili Domenico

Abstract excerpt

FoxO1 integrates multiple metabolic pathways. Nutrient levels modulate FoxO1 acetylation, but the functional consequences of this posttranslational modification are unclear. To answer this question, we generated mice bearing alleles that encode constitutively acetylated and acetylation-defective FoxO1 proteins. Homozygosity for an allele mimicking constitutive acetylation (Foxo1(KQ/KQ)) results in embryonic...

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Share to Acetylation
Share to Adipose Tissue

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Diet, High-Fat

Share to Forkhead Box Protein O1

Share to Forkhead Transcription Factors

Share to Gene Knock-In Techniques

Share to Lipid Metabolism

Share to Receptor, Insulin

Source

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Identifiers

PMID: 22055502
DOI: 10.1016/j.cmet.2011.09.012
PMCID: PMC3221516

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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