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Article

Diacylglycerol acyltransferase-1 (DGAT1) inhibition perturbs postprandial gut hormone release.

PloS one - 1 Jan 2013

Lin Hua V, Chen Dunlu, Shen Zhu, Zhu Lei, Ouyang Xuesong, Vongs Aurawan, Kan Yanqing, Levorse John M, Kowalik Edward J, Szeto Daphne M, Yao Xiaorui, Xiao Jianying, Chen Shirley, Liu Jinqi, Garcia-Calvo Marga, Shin Myung K, Pinto Shirly

Abstract excerpt

Diacylglycerol acyltransferase-1 (DGAT1) is a potential therapeutic target for treatment of obesity and related metabolic diseases. However, the degree of DGAT1 inhibition required for metabolic benefits is unclear. Here we show that partial DGAT1 deficiency in mice suppressed postprandial triglyceridemia, led to elevations in glucagon-like peptide-1 (GLP-1) and peptide YY (PYY) only following meals with very...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 23336002
DOI: 10.1371/journal.pone.0054480
PMCID: PMC3545956

Genes

DGAT1
PYY

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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