Article
GLUT4 glucose transporter deficiency increases hepatic lipid production and peripheral lipid utilization.
The Journal of clinical investigation - 1 Dec 2004
Kotani Ko, Peroni Odile D, Minokoshi Yasuhiko, Boss Olivier, Kahn Barbara B
Abstract excerpt
A critical defect in type 2 diabetes is impaired insulin-stimulated glucose transport and metabolism in muscle and adipocytes. To understand the metabolic adaptations this elicits, we generated mice with targeted disruption of the GLUT4 glucose transporter in both adipocytes and muscle (AMG4KO). In contrast to total body GLUT4-null mice, AMG4KO mice exhibit normal growth, development, adipose mass, and longevity....
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