Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genome maintenance defects in cultured cells and mice following partial inactivation of the essential cell cycle checkpoint gene Hus1.

Molecular and cellular biology - 1 Mar 2007

Levitt Peter S, Zhu Min, Cassano Amy, Yazinski Stephanie A, Liu Houchun, Darfler Joshua, Peters Rachel M, Weiss Robert S

Abstract excerpt

Cell cycle checkpoints are evolutionarily conserved signaling pathways that uphold genomic integrity. Complete inactivation of the mouse checkpoint gene Hus1 results in chromosomal instability, genotoxin hypersensitivity, and embryonic lethality. To determine the functional consequences of partial Hus1 impairment, we generated an allelic series in which Hus1 expression was incrementally reduced by combining a...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Cycle
Share to Cell Cycle Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Chromosomes, Mammalian

Share to DNA Damage

Share to DNA Replication

Share to Genome

Share to Genomic Instability

Share to Mice, Knockout

Source

Open in PubMed Open full text

Identifiers

PMID: 17220276
DOI: 10.1128/MCB.01763-06
PMCID: PMC1820507

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genome maintenance defects in cultured cells and mice following partial inactivation of the essential cell cycle checkpoint gene Hus1.PMID 17220276Read ↗

Increased common fragile site expression, cell proliferation defects, and apoptosis following conditional inactivation of mouse Hus1 in primary cultured cells.Semantic proximity Read ↗

Conditional inactivation of the mouse Hus1 cell cycle checkpoint gene.Semantic proximity Read ↗

Mice hypomorphic for Atr have increased DNA damage and abnormal checkpoint response.Semantic proximity Read ↗

Caenorhabditis elegans HUS-1 is a DNA damage checkpoint protein required for genome stability and EGL-1-mediated apoptosis.Semantic proximity Read ↗

Exonuclease-1 deletion impairs DNA damage signaling and prolongs lifespan of telomere-dysfunctional mice.Semantic proximity Read ↗

Longevity mutation in SCH9 prevents recombination errors and premature genomic instability in a Werner/Bloom model system.Semantic proximity Read ↗

Genetic determinants of micronucleus formation in vivo.Semantic proximity Read ↗

DNA repair in cardiomyocytes is critical for maintaining cardiac function in miceSemantic proximity Read ↗

Cell autonomous and nonautonomous mechanisms drive hematopoietic stem/progenitor cell loss in the absence of DNA repair.Semantic proximity Read ↗

Mouse embryonic stem cells carrying one or two defective Msh2 alleles respond abnormally to oxidative stress inflicted by low-level radiation.Semantic proximity Read ↗

Protecting genomic integrity in somatic cells and embryonic stem cells.Semantic proximity Read ↗

Homologous recombination is responsible for cell death in the absence of the Sgs1 and Srs2 helicases.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.