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Caenorhabditis elegans HUS-1 is a DNA damage checkpoint protein required for genome stability and EGL-1-mediated apoptosis.

Current biology : CB - 19 Nov 2002

Hofmann E Randal, Milstein Stuart, Boulton Simon J, Ye Mianjia, Hofmann Jen J, Stergiou Lilli, Gartner Anton, Vidal Marc, Hengartner Michael O

Abstract excerpt

BACKGROUND: The inability to efficiently repair DNA damage or remove cells with severely damaged genomes has been linked to several human cancers. Studies in yeasts and mammals have identified several genes that are required for proper activation of cell cycle checkpoints following various types...

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PMID: 12445383
DOI: 10.1016/s0960-9822(02)01262-9

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-12445383-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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