Article
Mouse embryonic stem cells carrying one or two defective Msh2 alleles respond abnormally to oxidative stress inflicted by low-level radiation.
Proceedings of the National Academy of Sciences of the United States of America - 29 Sept 1998
DeWeese T L, Shipman J M, Larrier N A, Buckley N M, Kidd L R, Groopman J D, Cutler R G, te Riele H, Nelson W G
Abstract excerpt
Chronic oxidative stress may play a critical role in the pathogenesis of many human cancers. Here, we report that mouse embryonic stem (ES) cells deficient in DNA mismatch repair responded abnormally when exposed to low levels of ionizing radiation, a stress known to generate oxidative DNA damage...
Topics
- Alleles
- Animals
- Apoptosis
- Cell Line
- Colorectal Neoplasms, Hereditary Nonpolyposis
- DNA Damage
- DNA Repair
- DNA-Binding Proteins
- Heterozygote
- Humans
- Mice
- MutS Homolog 2 Protein
- Mutation
- Oxidative Stress