Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mouse embryonic stem cells carrying one or two defective Msh2 alleles respond abnormally to oxidative stress inflicted by low-level radiation.

Proceedings of the National Academy of Sciences of the United States of America - 29 Sept 1998

DeWeese T L, Shipman J M, Larrier N A, Buckley N M, Kidd L R, Groopman J D, Cutler R G, te Riele H, Nelson W G

Abstract excerpt

Chronic oxidative stress may play a critical role in the pathogenesis of many human cancers. Here, we report that mouse embryonic stem (ES) cells deficient in DNA mismatch repair responded abnormally when exposed to low levels of ionizing radiation, a stress known to generate oxidative DNA damage. ES cells derived from mice carrying either one or two disrupted Msh2 alleles displayed an increased survival...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alleles
Share to Cell Line

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to DNA-Binding Proteins

Share to DNA Repair

Share to Heterozygote

Share to Mutation

Share to Proto-Oncogene Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 9751765
DOI: 10.1073/pnas.95.20.11915
PMCID: PMC21740

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mouse embryonic stem cells carrying one or two defective Msh2 alleles respond abnormally to oxidative stress inflicted by low-level radiation.PMID 9751765Read ↗

Methylation tolerance in mismatch repair proficient cells with low MSH2 protein level.Semantic proximity Read ↗

Increased ionizing radiation sensitivity and genomic instability in the absence of histone H2AX.Semantic proximity Read ↗

Inactivation of the mouse Msh2 gene results in mismatch repair deficiency, methylation tolerance, hyperrecombination, and predisposition to cancer.Semantic proximity Read ↗

The role of DNA damage repair in aging of adult stem cellsSemantic proximity Read ↗

DNA Damage in Stem Cells.Semantic proximity Read ↗

Loss of Msh2 and a single-radiation hit induce common, genome-wide, and persistent epigenetic changes in the intestineSemantic proximity Read ↗

Genetic analysis of mouse embryonic stem cells bearing Msh3 and Msh2 single and compound mutations.Semantic proximity Read ↗

Multiple Facets of the DNA Damage Response Contribute to the Radioresistance of Mouse Mesenchymal Stromal Cell LinesSemantic proximity Read ↗

DNA repair in murine embryonic stem cells and differentiated cells.Semantic proximity Read ↗

Mismatch repair deficiencies transforming stem cells into cancer stem cells and therapeutic implicationsSemantic proximity Read ↗

Embryonic Stem Cell-Specific Responses to DNA Replication StressSemantic proximity Read ↗

Oxidative Stress and the DNA Mismatch Repair PathwaySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.