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Article

DNA repair in cardiomyocytes is critical for maintaining cardiac function in mice

8 Feb 2023

Abstract excerpt

Heart failure has reached epidemic proportions in a progressively ageing population. The molecular mechanisms underlying heart failure remain elusive, but evidence indicates that DNA damage is enhanced in failing hearts. Here, we tested the hypothesis that endogenous DNA repair in cardiomyocytes is critical for maintaining normal cardiac function, so that perturbed repair of spontaneous DNA damage drives early...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 36756698
DOI: 10.1111/acel.13768

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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