Homologous recombination is responsible for cell death in the absence of the Sgs1 and Srs2 helicases.

Abstract excerpt

DNA helicases are involved in many aspects of DNA metabolism, including transcription, replication, recombination and repair. In the yeast Saccharomyces cerevisiae, the absence of the Sgs1 helicase results in genomic instability and accelerated ageing. In human cells, mutations in orthologues of SGS1 lead to Bloom (BS), Werner (WS) or Rothmund-Thomson (RTS) syndromes, which are rare, autosomal recessive diseases...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Bloom Syndrome
• Share to Gamma Rays
• Share to Haploidy