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Article

Exonuclease-1 deletion impairs DNA damage signaling and prolongs lifespan of telomere-dysfunctional mice.

Cell - 7 Sept 2007

Schaetzlein Sonja, Kodandaramireddy N R, Ju Zhenyu, Lechel Andre, Stepczynska Anna, Lilli Dana R, Clark Alan B, Rudolph Cornelia, Kuhnel Florian, Wei Kaichun, Schlegelberger Brigitte, Schirmacher Peter, Kunkel Thomas A, Greenberg Roger A, Edelmann Winfried, Rudolph K Lenhard

Abstract excerpt

Exonuclease-1 (EXO1) mediates checkpoint induction in response to telomere dysfunction in yeast, but it is unknown whether EXO1 has similar functions in mammalian cells. Here we show that deletion of the nuclease domain of Exo1 reduces accumulation of DNA damage and DNA damage signal induction in telomere-dysfunctional mice. Exo1 deletion improved organ maintenance and lifespan of telomere-dysfunctional mice but...

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Source

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Identifiers

PMID: 17803909
DOI: 10.1016/j.cell.2007.08.029
PMCID: PMC2658812

Genes

EXO1
ATR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Exonuclease-1 deletion impairs DNA damage signaling and prolongs lifespan of telomere-dysfunctional mice.PMID 17803909Read ↗

Inactivation of Exonuclease 1 in mice results in DNA mismatch repair defects, increased cancer susceptibility, and male and female sterility.Semantic proximity Read ↗

Exonuclease 1 and its versatile roles in DNA repair.Semantic proximity Read ↗

Human Exonuclease 1 (EXO1) Regulatory Functions in DNA Replication with Putative Roles in CancerSemantic proximity Read ↗

EXO1 is critical for embryogenesis and the DNA damage response in mice with a hypomorphic Nbs1 allele.Semantic proximity Read ↗

Exonuclease 1-dependent and independent mismatch repair.Semantic proximity Read ↗

EXO1-A multi-tasking eukaryotic nuclease.Semantic proximity Read ↗

Role of EXO1 nuclease activity in genome maintenance, the immune response and tumor suppression in Exo1D173A miceSemantic proximity Read ↗

Role of EXO1 nuclease activity in genome maintenance, the immune response and tumor suppression in <i> Exo1 <sup>D173A</sup> </i> miceSemantic proximity Read ↗

Rif1 and Exo1 regulate the genomic instability following telomere losses.Semantic proximity Read ↗

Characterization of nuclease-dependent functions of Exo1p in Saccharomyces cerevisiae.Semantic proximity Read ↗

EXO1 contributes to telomere maintenance in both telomerase-proficient and telomerase-deficient Saccharomyces cerevisiae.Semantic proximity Read ↗

Mrc1 protects uncapped budding yeast telomeres from exonuclease EXO1.Semantic proximity Read ↗

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