Article
Longevity mutation in SCH9 prevents recombination errors and premature genomic instability in a Werner/Bloom model system.
The Journal of cell biology - 14 Jan 2008
Madia Federica, Gattazzo Cristina, Wei Min, Fabrizio Paola, Burhans William C, Weinberger Martin, Galbani Abdoulaye, Smith Jesse R, Nguyen Christopher, Huey Selina, Comai Lucio, Longo Valter D
Abstract excerpt
Werner and Bloom syndromes are human diseases characterized by premature age-related defects including elevated cancer incidence. Using a novel Saccharomyces cerevisiae model system for aging and cancer, we show that cells lacking the RecQ helicase SGS1 (WRN and BLM homologue) undergo premature age-related changes, including reduced life span under stress and calorie restriction (CR), G1 arrest defects,...
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