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Article

Mice hypomorphic for Atr have increased DNA damage and abnormal checkpoint response.

Mammalian genome : official journal of the International Mammalian Genome Society - 1 Jun 2009

Ragland Ryan L, Arlt Martin F, Hughes Elizabeth D, Saunders Thomas L, Glover Thomas W

Abstract excerpt

The ATR checkpoint pathway responds to DNA damage during the S/G2 phases of the cell cycle and is activated early in tumorigenesis. Investigation of ATR's role in development and tumorigenesis is complicated by the lethality of homozygous knockout mice and the limited effects of heterozygous defi...

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Source

Identifiers

PMID: 19504344
DOI: 10.1007/s00335-009-9195-4

Genes

ATR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-19504344-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

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Mice hypomorphic for Atr have increased DNA damage and abnormal checkpoint response.PMID 19504344Read ↗

A mouse model of ATR-Seckel shows embryonic replicative stress and accelerated aging.Semantic proximity Read ↗

Targeted disruption of the cell-cycle checkpoint gene ATR leads to early embryonic lethality in mice.Semantic proximity Read ↗

Seckel syndrome exhibits cellular features demonstrating defects in the ATR-signalling pathwaySemantic proximity Read ↗

Primary microcephaly, impaired DNA replication, and genomic instability caused by compound heterozygous ATR mutations.Semantic proximity Read ↗

Genome maintenance defects in cultured cells and mice following partial inactivation of the essential cell cycle checkpoint gene Hus1.Semantic proximity Read ↗

CtIP Mutations Cause Seckel and Jawad SyndromesSemantic proximity Read ↗

Chk1 is an essential kinase that is regulated by Atr and required for the G(2)/M DNA damage checkpoint.Semantic proximity Read ↗

ATR suppresses endogenous DNA damage and allows completion of homologous recombination repair.Semantic proximity Read ↗

Identification of the First ATRIP–Deficient Patient and Novel Mutations in ATR Define a Clinical Spectrum for ATR–ATRIP Seckel SyndromeSemantic proximity Read ↗

ATR disruption leads to chromosomal fragmentation and early embryonic lethality.Semantic proximity Read ↗

Chromosomal instability at common fragile sites in Seckel syndrome.Semantic proximity Read ↗

Germline mutation in ATR in autosomal- dominant oropharyngeal cancer syndrome.Semantic proximity Read ↗

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