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Article

Cell autonomous and nonautonomous mechanisms drive hematopoietic stem/progenitor cell loss in the absence of DNA repair.

Stem cells (Dayton, Ohio) - 1 Mar 2013

Cho Joon Seok, Kook Sung Ho, Robinson Andria Rasile, Niedernhofer Laura J, Lee Byeong-Chel

Abstract excerpt

Daily, cells incur tens of thousands of DNA lesions caused by endogenous processes. Due to their long-lived nature, adult stem cells may be particularly susceptible to the negative impact of this constant genotoxic stress. Indeed, in murine models of DNA repair deficiencies, there is accumulation of DNA damage in hematopoietic stem cells and premature loss of function. Herein, we demonstrate that mice expressing...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 23097336
DOI: 10.1002/stem.1261
PMCID: PMC3582850

Genes

ERCC1

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