Article
Recombination signal sequence variations and the mechanism of patterned T-cell receptor-beta locus rearrangement.
Molecular immunology - 1 Mar 2004
Olaru Alexandru, Patterson Dimeka N, Cai Hongrong, Livák Ferenc
Abstract excerpt
Rearrangement of antigen receptor genes is controlled at multiple levels. One important regulation is achieved through variation in the recombination signals (RS) that flank the rearranging variable (V), diversity (D), and joining (J) gene segments. Several functional and biochemical studies have confirmed the importance of RS variations in gene rearrangement but very few molecular analyses has been reported with...
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