Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Control of antigen receptor diversity through spatial regulation of V(D)J recombination.

Cold Spring Harbor symposia on quantitative biology - 1 Jan 2013

Ebert Anja, Medvedovic Jasna, Tagoh Hiromi, Schwickert Tanja A, Busslinger Meinrad

Abstract excerpt

Lymphocytes recognize a vast variety of pathogens by expressing a diverse repertoire of antigen receptor genes that are assembled by V(D)J recombination in immature B cells (Igh, Igk) and T cells (Tcrb, Tcra/d). V(D)J recombination takes place in the 3' proximal domain containing the D, J, and C gene segments, whereas 31 (Tcrb) to 200 (Igh) V genes are spread over a large region of 0.67 (Tcrb) to 3 (Igk) Mb...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antibodies
Share to B-Lymphocytes
Share to Chromatin

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Enhancer Elements, Genetic

Share to Lymphocytes

Share to Receptors, Antigen

Share to V(D)J Recombination

Share to VDJ Recombinases

Source

Identifiers

PMID: 24584058
DOI: 10.1101/sqb.2013.78.019943

Genes

CTCF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Control of antigen receptor diversity through spatial regulation of V(D)J recombination.PMID 24584058Read ↗

MECHANISM AND CONTROL OF V(D)J RECOMBINATION AT THE IMMUNOGLOBULIN HEAVY CHAIN LOCUSSemantic proximity Read ↗

Mechanisms that control antigen receptor variable region gene assembly.Semantic proximity Read ↗

Chromatin topology and the regulation of antigen receptor assembly.Semantic proximity Read ↗

Dynamic regulation of antigen receptor gene assembly.Semantic proximity Read ↗

Regulation of V(D)J recombination.Semantic proximity Read ↗

Genetic and epigenetic control of V gene rearrangement frequency.Semantic proximity Read ↗

Molecular genetics at the T-cell receptor beta locus: insights into the regulation of V(D)J recombination.Semantic proximity Read ↗

Epigenetic control of Tcrb gene rearrangement.Semantic proximity Read ↗

V(D)J Recombination: Molecular Biology and RegulationSemantic proximity Read ↗

Gene segment selection in V(D)J recombination: accessibility and beyond.Semantic proximity Read ↗

Non-canonical D1-D2 recombination produces two types of rearrangements and represents a conservative hidden stage of T-cell receptor beta chain generationSemantic proximity Read ↗

Incorporation of multiple diversity genes in the TCRδ chain is highly regulated and evolutionarily conserved.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.