Control of antigen receptor diversity through spatial regulation of V(D)J recombination.

doi:10.1101/sqb.2013.78.019943

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Article

Control of antigen receptor diversity through spatial regulation of V(D)J recombination.

Cold Spring Harbor symposia on quantitative biology - 1 Jan 2013

Ebert Anja, Medvedovic Jasna, Tagoh Hiromi, Schwickert Tanja A, Busslinger Meinrad

Abstract excerpt

Lymphocytes recognize a vast variety of pathogens by expressing a diverse repertoire of antigen receptor genes that are assembled by V(D)J recombination in immature B cells (Igh, Igk) and T cells (Tcrb, Tcra/d). V(D)J recombination takes place in the 3' proximal domain containing the D, J, and C gene segments, whereas 31 (Tcrb) to 200 (Igh) V genes are spread over a large region of 0.67 (Tcrb) to 3 (Igk) Mb...

Topics

Alleles
Animals
Antibodies
B-Lymphocytes
Chromatin
Enhancer Elements, Genetic
Humans
Lymphocytes
Mice
Models, Genetic
Multigene Family
Mutagenesis
Protein Binding
Receptors, Antigen
Transcription Factors
V(D)J Recombination
VDJ Recombinases

Source

Open in PubMed

Identifiers

PMID: 24584058
DOI: 10.1101/sqb.2013.78.019943

Genes

CTCF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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