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Article

Locus folding mechanisms determine modes of antigen receptor gene assembly.

The Journal of experimental medicine - 5 Feb 2024

Allyn Brittney M, Hayer Katharina E, Oyeniran Clement, Nganga Vincent, Lee Kyutae, Mishra Bikash, Sacan Ahmet, Oltz Eugene M, Bassing Craig H

Abstract excerpt

The dynamic folding of genomes regulates numerous biological processes, including antigen receptor (AgR) gene assembly. We show that, unlike other AgR loci, homotypic chromatin interactions and bidirectional chromosome looping both contribute to structuring Tcrb for efficient long-range V(D)J recombination. Inactivation of the CTCF binding element (CBE) or promoter at the most 5'Vβ segment (Trbv1) impaired loop...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 38189780
DOI: 10.1084/jem.20230985
PMCID: PMC10772921

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