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Article

How to keep V(D)J recombination under control.

Immunological reviews - 1 Aug 2004

Oettinger Marjorie A

Abstract excerpt

Breaking apart chromosomes is not a matter to be taken lightly. The possible negative outcomes are obvious: loss of information, unstable chromosomes, chromosomal translocations, tumorigenesis, or cell death. Utilizing DNA rearrangement to generate the desired diversity in the antigen receptor loci is a risky business, and it must be carefully controlled. In general, the regulation is so precise that the negative...

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Source

Identifiers

PMID: 15242404
DOI: 10.1111/j.0105-2896.2004.00172.x

Genes

RAG1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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