Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Evolution of the variable gene segments and recombination signal sequences of the human T-cell receptor alpha/delta locus.

Immunogenetics - 1 Oct 2004

Haynes Marsha R, Wu Gillian E

Abstract excerpt

The T-cell receptor (TCR) alpha and delta loci are particularly interesting because of their unique genomic structure, in that the gene segments for each locus are interspersed. The origin of this remarkable gene segment arrangement is obscure. In this report, we investigated the evolution of the TCRalpha and delta variable loci and their respective recombination signal sequences (RSSs). Our phylogenetic analyses...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chromosomes, Human, Pair 14
Share to Complementarity Determining Regions

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Immunoglobulin J-Chains

Share to Immunoglobulin Light Chains

Share to Immunoglobulin Variable Region

Share to Protein Sorting Signals

Share to Receptors, Antigen, T-Cell, alpha-beta

Share to Receptors, Antigen, T-Cell, gamma-delta

Source

Identifiers

PMID: 15378298
DOI: 10.1007/s00251-004-0706-x

Genes

CDR2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Evolution of the variable gene segments and recombination signal sequences of the human T-cell receptor alpha/delta locus.PMID 15378298Read ↗

Human T-cell receptor variable gene segment families.Semantic proximity Read ↗

The Human T Cell Receptor Alpha Variable (TRAV) GenesSemantic proximity Read ↗

Non-canonical D1-D2 recombination produces two types of rearrangements and represents a conservative hidden stage of T-cell receptor beta chain generationSemantic proximity Read ↗

Incorporation of multiple diversity genes in the TCRδ chain is highly regulated and evolutionarily conserved.Semantic proximity Read ↗

[T-lymphocyte receptor genes: genome organization and genetic mechanisms of repertoire diversity].Semantic proximity Read ↗

Distinct evolution at TCRα and TCRβ loci in the genus <i>Mus</i>Semantic proximity Read ↗

Diversity and evolution of T-cell receptor variable region genes in mammals and birds.Semantic proximity Read ↗

Organization of the human T-cell receptor genes.Semantic proximity Read ↗

Systematic study of human alpha beta T cell receptor V segments shows allelic variations resulting in a large number of distinct T cell receptor haplotypes.Semantic proximity Read ↗

The Complete Nucleotide Sequence of the Human Immunoglobulin Heavy Chain Variable Region LocusSemantic proximity Read ↗

Preferential rearrangements of the T cell receptor-delta-deleting elements in human T cells.Semantic proximity Read ↗

Organization of the V gene segments in mouse T-cell antigen receptor alpha/delta locus.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.