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Article

Dual selection pressure by drugs and HLA class I-restricted immune responses on human immunodeficiency virus type 1 protease.

Journal of virology - 1 Mar 2007

Mueller Sandra M, Schaetz Birgit, Eismann Kathrin, Bergmann Silke, Bauerle Michael, Schmitt-Haendle Matthias, Walter Hauke, Schmidt Barbara, Korn Klaus, Sticht Heinrich, Spriewald Bernd, Harrer Ellen G, Harrer Thomas

Abstract excerpt

To determine the influence of human immunodeficiency virus type 1 (HIV-1)-specific CD8+ T cells on the development of drug resistance mutations in the HIV-1 protease, we analyzed protease sequences from viruses from a human leukocyte antigen class I (HLA class I)-typed cohort of 94 HIV-1-positive individuals. In univariate statistical analyses (Fisher's exact test), minor and major drug resistance mutations as...

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Share to CD4 Lymphocyte Count
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Epitopes, T-Lymphocyte

Share to Histocompatibility Antigens Class I

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Share to Leukocytes, Mononuclear

Source

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Identifiers

PMID: 17202219
DOI: 10.1128/JVI.01547-06
PMCID: PMC1866003

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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