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Article

Systematic screening of viral and human genetic variation identifies antiretroviral resistance and immune escape link.

eLife - 1 Jun 2021

Nguyen Huyen, Thorball Christian Wandell, Fellay Jacques, Böni Jürg, Yerly Sabine, Perreau Matthieu, Hirsch Hans H, Kusejko Katharina, Thurnheer Maria Christine, Battegay Manuel, Cavassini Matthias, Kahlert Christian R, Bernasconi Enos, Günthard Huldrych F, Kouyos Roger D

Abstract excerpt

Background: Considering the remaining threat of drug-resistantmutations (DRMs) to antiretroviral treatment (ART) efficacy, we investigated how the selective pressure of human leukocyte antigen (HLA)-restricted cytotoxic T lymphocytes drives certain DRMs' emergence and retention. Methods: We systematically screened DRM:HLA class I allele combinations in 3997 ART-naïve Swiss HIV Cohort Study (SHCS) patients. For...

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Share to Anti-Retroviral Agents
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34061023
DOI: 10.7554/eLife.67388
PMCID: PMC8169104

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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