Article
Resistance of human immunodeficiency virus type 1 to protease inhibitors: selection of resistance mutations in the presence and absence of the drug.
The Journal of general virology - 1 Mar 1996
Borman A M, Paulous S, Clavel F
Abstract excerpt
Inhibitors of the human immunodeficiency virus (HIV) protease are a promising class of antiviral agents that dramatically reduce HIV replication both in culture and in infected patients. However, as for many other antiviral compounds, long-term efficacy of these agents is impeded by the emergence...
Topics
- Amino Acid Sequence
- Antiviral Agents
- Base Sequence
- DNA Primers
- Drug Resistance, Microbial
- HIV Protease Inhibitors
- HIV-1
- HeLa Cells
- Humans
- Methylurea Compounds
- Molecular Sequence Data
- Mutation
- Pyridines
- Valine