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Article

Antiretroviral drug resistance mutations sustain or enhance CTL recognition of common HIV-1 Pol epitopes.

Journal of immunology (Baltimore, Md. : 1950) - 1 Jun 2004

Mason Rosemarie D, Bowmer M Ian, Howley Constance M, Gallant Maureen, Myers Jennifer C E, Grant Michael D

Abstract excerpt

Antiretroviral drug resistance and escape from CTL are major obstacles to effective control of HIV replication. To investigate the possibility of combining drug and immune-based selective pressures against HIV, we studied the effects of antiretroviral drug resistance mutations on CTL recognition of five HIV-1 Pol epitopes presented by common HLA molecules. We found that these common drug resistance mutations...

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Share to Acquired Immunodeficiency Syndrome
Share to Epitopes, T-Lymphocyte

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Products, pol

Share to HIV Reverse Transcriptase

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Share to HLA-A3 Antigen

Share to Interferon-gamma

Share to T-Lymphocytes, Cytotoxic

Source

Identifiers

PMID: 15153547
DOI: 10.4049/jimmunol.172.11.7212

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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