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Article

Selective pressures of HLA genotypes and antiviral therapy on human immunodeficiency virus type 1 sequence mutation at a population level.

Clinical and vaccine immunology : CVI - 1 Oct 2007

Ahlenstiel Golo, Roomp Kirsten, Däumer Martin, Nattermann Jacob, Vogel Martin, Rockstroh Jürgen K, Beerenwinkel Niko, Kaiser Rolf, Nischalke Hans-Dieter, Sauerbruch Tilman, Lengauer Thomas, Spengler Ulrich

Abstract excerpt

The objective of this study was a comprehensive analysis of the immune-driven evolution of viruses of human immunodeficiency virus type 1 (HIV-1) clade B in a large patient cohort treated at a single hospital in Germany and its implications for antiretroviral therapy. We examined the association of the HLA-A, HLA-B, and HLA-DRB1 alleles with the emergence of mutations in the complete protease gene and the first...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 17715334
DOI: 10.1128/CVI.00169-07
PMCID: PMC2168106

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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