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Article

Interactive selective pressures of HLA-restricted immune responses and antiretroviral drugs on HIV-1.

Antiviral therapy - 1 Jan 2005

John Mina, Moore Corey B, James Ian R, Mallal Simon A

Abstract excerpt

HIV-specific cytotoxic T lymphocyte (CTL) responses mediated by human leukocyte antigen (HLA) recognition and antiretroviral drugs exert selection pressure on HIV-1 in vivo. The selection of CTL escape mutations strongly underpins the failure of CTL control in most untreated infections whilst drug-resistance mutations predict failure of drug control. These two evolutionary forces share common target residues in...

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Source

Identifiers

PMID: 16038481

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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