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Article

Dual pressure from antiretroviral therapy and cell-mediated immune response on the human immunodeficiency virus type 1 protease gene.

Journal of virology - 1 Jun 2003

Karlsson Annika C, Deeks Steven G, Barbour Jason D, Heiken Brandon D, Younger Sophie R, Hoh Rebecca, Lane Meghan, Sällberg Matti, Ortiz Gabriel M, Demarest James F, Liegler Teri, Grant Robert M, Martin Jeffrey N, Nixon Douglas F

Abstract excerpt

Human immunodeficiency virus (HIV)-specific CD8(+) T-lymphocyte pressure can lead to the development of viral escape mutants, with consequent loss of immune control. Antiretroviral drugs also exert selection pressures on HIV, leading to the emergence of drug resistance mutations and increased levels of viral replication. We have determined a minimal epitope of HIV protease, amino acids 76 to 84, towards which a...

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Share to Antiretroviral Therapy, Highly Active
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Drug Resistance, Viral

Share to Epitopes, T-Lymphocyte

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Source

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Identifiers

PMID: 12767994
DOI: 10.1128/jvi.77.12.6743-6752.2003
PMCID: PMC156163

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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