Article
Mapping of susceptibility and protective loci for acute GVHD in unrelated HLA-matched bone marrow transplantation donors and recipients using 155 microsatellite markers on chromosome 22.
Immunogenetics - 1 Feb 2007
Kikuchi Tomoki, Naruse Taeko K, Onizuka Makoto, Li Suyun, Kimura Tetsuaki, Oka Akira, Morishima Yasuo, Kulski Jerzy K, Ichimiya Shingo, Sato Noriyuki, Inoko Hidetoshi
Abstract excerpt
Despite matching donors and recipients for the human leukocyte antigens (HLAs) expressed by the major histocompatibility genomic region of the short arm of chromosome 6, several recipients still develop acute graft-versus-host disease (aGVHD) after bone marrow transplantation (BMT). This is possibly due to non-HLA gene polymorphisms, such as minor histocompatibility antigens (mHas) and genes coding for cytokines....
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