Article
Genetic risk factors for sclerotic graft-versus-host disease.
Blood - 15 Sept 2016
Inamoto Yoshihiro, Martin Paul J, Flowers Mary E D, Lee Stephanie J, Carpenter Paul A, Warren Edus H, Geraghty Daniel E, Lee Ni, Boeckh Michael J, Storer Barry E, Levine David M, Fan Wenhong, Zhao Lue-Ping, Hansen John A
Abstract excerpt
Sclerotic graft-versus-host disease (GVHD) is a distinctive phenotype of chronic GVHD after allogeneic hematopoietic cell transplantation, characterized by fibrosis of skin or fascia. Sclerotic GVHD has clinical and histopathological similarities with systemic sclerosis, an autoimmune disease whose risk is influenced by genetic polymorphisms. We examined 13 candidate single-nucleotide polymorphisms (SNPs) that...
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