Article
Risk model incorporating donor IL6 and IFNG genotype and gastrointestinal GVHD can discriminate patients at high risk of steroid refractory acute GVHD.
Bone marrow transplantation - 1 May 2015
Alam N, Xu W, Atenafu E G, Uhm J, Seftel M, Gupta V, Kuruvilla J, Lipton J H, Messner H A, Kim D D H
Abstract excerpt
Steroid refractory acute GVHD (SR aGVHD) is associated with high morbidity and mortality. This study attempted to generate a risk model for SR aGVHD using 259 single nucleotide polymorphisms (SNPs) in 53 genes of recipients and donors. A total of 268 patients with aGVHD who were treated with systemic steroids were included. Patients were randomly divided into training (n=180) and validation sets (n=88). Clinical...
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