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Article

Autosomal Minor Histocompatibility Antigens: How Genetic Variants Create Diversity in Immune Targets

15 Mar 2016

Abstract excerpt

Allogeneic stem cell transplantation (alloSCT) can be a curative treatment for hematological malignancies. Unfortunately, the desired anti-tumor or graft-versus-leukemia (GvL) effect is often accompanied with undesired side effects against healthy tissues known as graft-versus-host disease (GvHD). After HLA-matched alloSCT, GvL and GvHD are both mediated by donor-derived T-cells recognizing polymorphic peptides...

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PMID: 27014279
DOI: 10.3389/fimmu.2016.00100

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