Article
Multiple single-nucleotide polymorphism-based risk model for clinical outcomes after allogeneic stem-cell transplantation, especially for acute graft-versus-host disease.
Transplantation - 27 Dec 2012
Kim Dennis Dong Hwan, Yun Jina, Won Hong-Hee, Cheng Lu, Su Jie, Xu Wei, Uhm Jieun, Gupta Vikas, Kuruvilla John, Messner Hans A, Lipton Jeffrey H
Abstract excerpt
BACKGROUND: We aimed to develop multiple single-nucleotide polymorphism (SNP)-based risk models associated with the risk of transplant outcomes including graft-versus-host disease (GVHD). METHODS: The study evaluated 259 SNPs in 53 genes in 394 pairs of donors and recipients. In a discovery set (n=307 receiving related donor transplantation), overall survival, relapse-free survival (RFS), nonrelapse mortality,...
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